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Objective To learn the epidemic characteristics of metabolic syndrome (MS)among rural adults in Changshan County and to provide evidence for developing control and prevention measures.Methods A total of 1 21 2 residents aged over 1 8 years old in four towns were selected by multi -stage stratified cluster random sampling method and an investigation including questionnaire,physical examination and blood biochemical examination was conducted.Results The crude prevalence rate of MS among rural adults in Changshan County was 30.61 % and the standardized prevalence rate was 26.32%.The MS prevalence rate was significantly higher in females than in males (P <0.01 ).The major risk factors for MS were female gender (OR =1 .98),elderly age (OR =1 .02)and family history of hypertension (OR =1 .60). Conclusion The prevalence rate of MS is considerably high in rural areas of Changshan County and effective measures should be taken at early stage.
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<p><b>OBJECTIVE</b>To compare the effects of piglitazone and metformin on retinol-binding protein-4 (RBP-4) and adiponcetin (APN) in patients with type 2 diabetes mellitus (T2DM) complicated with Non alcohol fatty acid liver disease (NAFLD).</p><p><b>METHODS</b>Totally 60 T2DM patients complicated with NAFLD were equally and randomly divided into pioglitazone group and metform group. The levels of biochemical indicators including body mass index (BMI), glucose hemoglobin A1C (GHbA1C), insulin resistance (HOMA-IR), fasting blood glucose (FBG), fasting insulin (FIns), and serum triglycerides (TG) as well as serum RBP-4 and APN level were measured pre-treatment and 12 weeks after treatments.</p><p><b>RESULTS</b>After 12 weeks of treaments, BMI, FBG, HOMA-IR, GHbA1C, FIns, and TG decreased (all P<0.05) in both piglitazone group and metform group. APN increased (all P<0.05) in both groups. RBP-4 decreased (P<0.05) in piglitazone group. Compare with the metform group, the levels of RBP-4, FIns ,and HOMA-IR decreased and BMI increased in piglitazone group (P<0.05).</p><p><b>CONCLUSION</b>Piglitazone is superior to metoform in decreasing RBP-4 level and HOMA-IR in patients with T2DM complicated with NAFLD.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Adiponectin , Blood , Diabetes Mellitus, Type 2 , Blood , Drug Therapy , Fatty Liver , Blood , Metformin , Pharmacology , Retinol-Binding Proteins, Plasma , Metabolism , Thiazolidinediones , PharmacologyABSTRACT
Objective To investigate the relationship between the blood pressure in subjects with impaired glucose relation and the first-phase insulin secretion.Methods The oral glucose tolerance test was performed in 126 subjects who were divided into normal blood pressure group higher blood pressure group and hypertension group.The beta-cell function was calculated by HOMA-IR and △I30/△G30.Results ①The BMI and WHR were significantly higher in hypertension group.The serum level of lipids was changed in higher blood pressure and hypertension groups.② The fasting plasma insulin level,60、120 minutes insulin level after oral 75 game glucose were significantly higher in hypertension group.③ The HOMA-IR was significantly higher in higher blood pressure and hypertension groups,with more higher in hypertension group.④ The △I30/△G30 was significantly decrease in hypertension group.There are no different in other groups.Conclusion The higher blood pressure,the more severe insulin resistance,the more decrease first-phase insulin secretion.
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Objective To observe the effect of low molecular weight heparin(LMWH) in treatment of diabetic foot.Methods Fifty-four patients were divided into test group and control group randomly.Both two groups were given routine therapy including mediating blood glucose with Insulin,anti-infection and changing dressings,while the test group were givon LMWH 5000IU once datly every 12 hours for 15 days besides the routine treatment.Then the endothelin(ET),thromboxaneB2(TXB2),hemorheology,ankle-brachial index(ABI),ulcer healing,fibrinogen(FIB),prothrombin time(PT) and avtivated parital thromboplastin time(APTT) were observed.Results Compared to that of before treatment,there are ET,TXB2,hemorheology and better ulcer heals after treatment,The improvement in test group patients was superior to that of control group(P0.05) after treatment in two groups.No hemorrhage and other complications occurred.Conclusion LMWH is effective and safe for treatment of diabetic foot.
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Objective To study the relationship between diabetic foot(DF)and the change of blood fluidity.Methods The blood viscosity、plasma viscosity、hematocrit、erythrocyte sedimentation rate、fibrinogen were determined in 126 type 2 diabetes cases.They were divided into DF group and non-diabetic foot(NDF)group.Results ①The incidence of DF is higher in older and longer course of diabetes cases with renalpathy、neuropathy、peripheral artery disease and retinopathy.② The blood viscosity、plasma viscosity、hematocrit、erythrocyte sedimentation rate and fibrinogen are significantly higher in DF group.③ The indexes of blood fluidity are significantly higher in Ankle Brachial Index(ABI)abnormal group than normal group.Conclusions To have the blood fluidity under control effectively is very important for prevention and treatment of DF.